And, yes, you can add changes in intrathoracic pressure and see systolic pressure variation magnified by the presence of pericardial fluid! In the anesthesia input panel, you can toggle between spontaneous and mechanical ventilation. You can also select different degrees of lung stiffness (this will change the peak pressure for a set tidal volume with mechanical ventilation). If you view a monitor plot, you can see the pressure variation with the ventilatory cycle on the PA and ABP tracings. BTW, another fun example of systolic pressure variation can be seen if you turn on V-pacing at a slightly different rate than the atrial rate (set by HR)–atrial and ventricular contraction come in an out of phase, generating a-waves on the CVP tracing when the RA contracts against a closed tricuspid valve, and reducing LV filling during that phase. Endless fun with the simulator!