Harvi-ECMO explores gas exchange in the lungs, Oxygen Delivery, Fick Cardiac output, Control of Ventilation, causes of hypoxemia, and basic interpretation of the arterial blood gas measurements. These fundamental concepts are used to build an understanding o the physiology of V-V ECMO, including the hemodynamics of the circuit, interpretation of blood gases, membrane dysfunction, and recirculation. The third section explores the physiology of V-A ECMO including harlequin syndrome, ventricular distension and decompression strategies, additional mechanical circulatory devices alternative cannulation strategies (V-A-V ECMO) and acute pulmonary hypertension and RV support. All chapters contain guided tutorials and self assessment questions. This is part of the Harvi-ECMO/MCS program and includes access to large library of Try-It-Nows, basic and advanced courses in Harvi Academy, and access to the full Harvi Simulator with a larger selection of input and plot menus.